In a study conducted at the Universidad de Cantabria, Raquel Linge and her team performed a study using cannabidiol (CBD), the non-psychoactive seizure-stopping cannabinoid found in marijuana, to treat depression.
Cannabis reacts with different endocannabinoid receptors throughout the brain and body, thus producing different effects, and neuroscientists have witnessed how CBD affects serotonin and glutamate levels. These two neurotransmitters in the brain are what pharmaceuticals often target to treat the biological causes of depression.
The study used a mouse model called OBX that is often used to research depression in humans. It involves removing part of a mouse’s brain to trigger some of the symptoms of depression. The mice with the OBX surgery were compared with normal mice and both were administered CBD. Within 30 minutes, researchers noticed a significant reduction in hyperactivity, which could present as anxiety in humans. Over the course of a week, mice regained their ability to enjoy sugar. This characteristic is often translated into a human’s desire for enjoyment.
In both OBX mice and normal mice, researchers saw an increase in glutamate levels immediately, and they held over the course of the week. The serotonin levels were more subtle, and seemed to hold steady only in mice who had the OBX surgery, suggesting that it was a response based on the conditions of the brain.
There are a wide variety of pharmaceutical options on the market for treating depression, but all of them fall within nine main categories. Depression can have many different biological causes and the variety of treatment options help doctors narrow in on the best treatment for their patients. The promising data from this study suggests CBD could be used as a base for new treatment options. What’s more, the study indicates that the response to CBD was almost immediate, which is not the case for most conventional pharmaceutical treatments that take weeks or even months to balance out and produce desired effects.
Many are familiar with the major cannabinoids found in cannabis, such as THC and CBD, which have such great efficacy for conditions like depression, PTSD, and epilepsy. But cannabinoids are only part of the picture. Terpenes are like molecular cousins to cannabinoids and serve the primary role of delivering a wide variety of alluring aromas to cannabis flowers, but also offer a wide range of medicinal benefits as well.
In addition to aroma, terpenes deliver sometimes great medicinal value. They have been found to fight cancer and act as an analgesic (pain killer). Like amino acids, terpenes are powerful building blocks within the plant’s physiology that aid in the production of vitamins, hormones, pigments, resins, and — yes, that most prized part of the herb — cannabinoids. Cannabis plants release more terpenes when temperatures are higher (one reason they emit strong odors during the peak of harvest season).
More than 200 terpenes are available in the cannabis plant, while more than 20,000 exist in nature. They are produced in the small resin glands that appear primarily on the surface of the flowers and sugar leaves of cannabis plants called trichomes. It is estimated that there are nearly 1000 strains of cannabis that have been bred. Each of these features a distinct and unique mix of terpenes, something called a terpene profile.
Cannabis and cannabis products — such as concentrates — sold in legal and regulated states often feature a label providing a laboratory analysis that lists the exact percentages of cannabinoids and terpenes. Often, lab techs, budtenders, and pot nerds will discuss particular strains or extracts of cannabis in terms of their terpene profiles and how the overall efficacy of one profile (an individual of a particular strain) compares with other samples or methods of extracting concentrates.
Major terpenes include myrcene, pinene, and limonene. Myrcene, which conveys earthy and clove-like odors, determines whether a particular strain is indica or sativa by its percentage within the plant (further illustrating the important role played by terpenes). Pinene, a terpene also found in evergreens, has been found to increase mental focus and energy and acts as a bronchodilator — making it helpful for asthma sufferers. Limonene, as its name implies, provides an aroma of citrus and is found not only in cannabis, but also oranges, grapefruits, lemons, and limes. It has been revealed to alleviate depression and aid in digestion.
Terpenes are very volatile, delicate molecules that are easily destroyed by heat and oxidation. Popular cannabis concentrates, like BHO and CO2 oil, are mostly void of terpenes. One new extraction method called live resin preserves the terpene profile of cannabis plants. This process involves cryogenically freezing plants immediately after harvest and then using a laboratory extraction process (backyard brewers need not apply) to remove and isolate a more accurate representation of a particular plant’s mix of cannabinoids and terpenes.
What is Linalool?
Linalool, one of the minor terpenes found in cannabis, conveys a floral aroma, sometimes with a hint of spice. More than 200 species of plants produce linalool, including a variety of mints and herbs. More important, linalool serves many roles in relieving a number of symptoms, including pain, depression, seizures, inflammation (similar to limonene), and even insomnia (because it acts as a sedative). Its tranquilizing effects are helpful for those suffering with many types of psychosis.
- Analgesic: Linalool is helpful for conditions like multiple sclerosis, dystonia, arthritis, post-operative pain, and chronic pain from any source because it is a pain killer. Combined with cannabinoids of the same efficacy, linalool can be a reinforcing agent in a patient’s struggle to manage pain, especially if they are trying to avoid or reduce use of opiates such as Vicodin, Percocet, and Oxycontin.
- Antidepressant: More than 20 million people in the United States alone suffer from sometimes debilitating depression. This common psychological ailment can negatively affect one’s career, personal relationships, and even physical health. Linalool, when combined with cannabinoids like THC that are also effective in helping alleviate depression, helps form an overall strategy for using cannabis to treat these types of disorders.
- Anti-Convulsant: Just as chemotherapy is used to treat conditions other than cancer, seizures afflict those with conditions other than epilepsy, such as traumatic brain injury, brain tumors, and hydrocephalus. Most seizures feature a duration of between 30 seconds and two minutes. Typically, they do not cause lasting harm, although they seizures often very taxing, painful, or exhausting for sufferers. Seizures that last longer than five minutes are considered life threatening.
- Anti-Inflammatory: Those suffering from inflammation-based diseases, such as Crohn’s, arthritis, Alzheimer’s, asthma, fibromyalgia, dermatitis, IBS, lupus, and Parkinson’s, among many others, gain benefit from the anti-inflammatory properties of linalool (as well as a variety of anti-inflammatory cannabinoids).
- Sedative and Sleep Aid: It is estimated that 10-30 percent of people suffer from insomnia at some point in their lives, with 10 percent reported to experience chronic and severe sleep deprivation. Cannabinoids like CBN, when combined with terpenes such as linalool, help patients get the sleep they require to maintain homeostasis (balance) and health. Adequate sleep is critical for patients to most effectively fight their condition or disease.
Ancient cultures have used terpenes like linalool, available in a variety of aromatic herbs like cannabis, for millennia to treat a wide variety of conditions. 21st century research has confirmed the beliefs of these ancient civilizations, revealing strong medical efficacy for a variety of conditions.
A 2002 study published in the Journal of Phytomedicine revealed that linalool is a major anti-inflammatory agent, potentially helping with a variety of inflammation-related ailments, such as cancer, arthritis, and Crohn’s disease. The same research team, in a 2003 study, found linalool to also be a pain killer. These researchers again, in 2006, conducted another linalool study that further collected and examined data from animal models. This study reinforced the fact that linalool is a powerful anti-inflammatory.
2008 research published in the American Association of Nurse Anesthetists Journal supported the sedative qualities of linalool. The study estimated that 19 million Americans suffer from anxiety-related ailments, with 16 percent of people between the ages of 18 and 54 being patients of one or more anxiety conditions, which sometimes lead to substance abuse and mood disorders.
This study revealed linalool to be a powerful sedative that delivers real efficacy to those who suffer anxiety disorders and one of their most common side effects, insomnia. Concluded the study:
“Our data…suggested that linalool modulates the central nervous system by producing unconsciousness and degradation of motor movements.”
A 2010 study involving mice that employed three different sub-types of linalool found it to be an effective anticonvulsant, meaning it shows significant promise for those who suffer seizures, such as patients of epilepsy and brain tumors. Reported the study:
“Linalool…[was] effective in preventing tonic convulsions induced by transcorneal electroshock in the animals.”
More Research Needed
As with all areas of cannabis science, terpenes like linalool are in desperate need of well funded, robust research in the form of human trials. Until cannabis is dropped from Schedule I and real studies are permitted by reputable research institutions and laboratories, medical professionals and patients must play a guessing game in terms of the types and dosages of terpenes like linalool that are most appropriate for particular conditions.