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Care by Design 18:1 Sublingual Spray Review

Care by Design 18:1 Sublingual Spray Review

If you’ve ever taken more than the recommended dose of acetaminophen or ibuprofen, it’s often because more is needed. Maybe you’re suffering from the flu and need to break a fever, or have an especially bad headache. Most painkillers, prescription or over-the-counter, work in this way: more medicine means more relief.

One of the largest learning curves when it comes to cannabidiol is that it’s biphasic: more CBD does not necessarily mean more relief. It means different relief. The science of cannabinoids is still developing and there’s a lot of trial-and-error for patients and caregivers. The ratio of CBD to THC is also important rather than a straight dose of CBD. Researchers are unclear as to why small amounts of THC bring out the benefits of CBD, but they do. I’ve noticed a pattern that suggests the higher the ratio of CBD to THC, the better it works for medical conditions that are difficult to treat.

Multiple sclerosis, fibromyalgia and Dravet syndrome are diseases CBD can potentially treat when conventional methods have failed. MS an\d fibromyalgia occur often enough in the population that pharmaceutical companies have devoted resources towards developing new treatments, but Dravet syndrome is more rare. It presents in children less than a year old and is devastating to their quality of life. Treatments for epilepsy in general requires heavy doses of tranquilizing drugs, and this can cause long term harm to a growing child. CBD’s potential to treat Dravet syndrome is significant enough that pharmaceutical companies have taken notice and are studying CBD in full scale clinical trials.

I was curious if an 18:1 ratio could work for my seasonal affective disorder. Luckily, southern California has very few cloudy days, but those days can stop me in my tracks. Care by Design’s collection of CBD sprays has been great for my pain and IBS symptoms in lower ratios, but I didn’t notice any antidepressant qualities. During a rainy week, I tried their 18:1 sublingual spray.

Having used Care by Design’s sprays before, I knew 3-4 sprays works well for me. For reference, I’m 5’11” and height and weight should be considered when determining a proper dose. The company suggests 1-2 sprays and that is an excellent place to start for a full grown adult. While I’ve heard patients sometimes mix the spray into a drink or food, I would not recommend this when you’re relying on this medicine for acute conditions. I find the taste of the sprays to be very mild, but “chasing” the spray with water will all but eliminate the cannabis flavor after you’ve used the spray.

On a typical cloudy day, normal tasks require a lot of motivation for me. I have to force myself to get up, make coffee, read my email and so on. Each step feels like my mind and body are saying “NOPE.” After three sprays in the morning, it felt like a totally normal day. Compared to typical antidepressants, I noticed a change rather quickly. I also noticed when it tapered off in the afternoon, so I took 3 more sprays around 4pm. With a week’s worth of El Niño weather, I was able to see what daily use was like. It was a nice feeling to know that the spray works as needed and doesn’t linger in my system. I’m not opposed to long-term therapies at all, but I am opposed to taking something when it’s not necessary. As soon as the sun came back, I wanted to go back to my normal routine. Even when I was using the spray, it felt like my normal routine. I didn’t feel “high” or even a reduced amount of anxiety (there are other ratios and other cannabis products I would use for that effect). I simply was able to function normally without the heaviness that depression brings to the mind and body.

One of the great aspects of CBD, and cannabis in general, is that I experience no withdrawal. While there is anecdotal evidence that suggests marijuana withdrawal exists, I personally have not had that experience, nor have I with any CBD product (in contrast, my caffeine withdrawal symptoms might be the worst withdrawal I’ve ever experienced!). That can’t be said for prescription antidepressants, some of which can lead to seizures and comas when stopped abruptly. Because of this, antidepressants in general require a significant time commitment to see if they work, and more time to taper off should they be ineffective or produce unwanted side effects. For those who experience temporary depressions, this could be an option in dealing with those situations. Depression is a complicated illness with many causes and even more treatment options, and this product is unique among those options.

In choosing a CBD treatment, dosage is critical. Care by Design thoroughly tests their products, and I’m confident that I’m getting what I pay for when I choose their products. CBD products are an investment and Care by Design has taken steps to establish trust with patients by being transparent about their manufacturing process and their testing. I will continue to search for their products when looking for a reliable CBD medication.

 

Photo credit: Care By Design

Innovative Cannabis Concentrate Vaporizer Hits Market

Innovative Cannabis Concentrate Vaporizer Hits Market

A dab rig and a crockpot had a baby, and it’s disrupting the world of cannabis concentrate vaporization.

The Vapor Brothers, inventors of the very first functionally successful box and whip vaporizer for cannabis flowers, have launched a new product for cannabis concentrates — the VB2. Just as the VB1 revolutionized vaping flowers, the VB2 is changing the game for patients and recreational consumers of cannabis concentrates.

Inspiration

The story behind the development of the VB2 multi-converter is heart warming. Inspired by a friend who was paralyzed and suffered from such constant, chronic pain that she had to smoke, vape and eat cannabis all day or otherwise take handfuls of pharmaceutical medications that produced debilitating side effects, inventor Linus Vapor thought there must be a more efficient way to deliver cannabinoid therapy.

Thus the VB2 was born to deliver the maximum amount of concentrated medicine in one hit from a vaporizer, arguably the healthiest method of cannabis consumption.

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Drop dabs of your favorite concentrates like bubble hash, butane hash oil (BHO), rosin, or live resin into the hole in the top of the VB2, and it will land on a 1,000 degree ceramic surface that quickly transforms the concentrate into vapor for rapid inhalation.

The ceramic surface, which experts say are best for maintaining the integrity of the cannabis product’s terpene profile and therefore taste, is the perfect size and position for taking both large and small draws.

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The glass top keeps the vapor contained, allowing for smooth hits of solid, thick vapor, and the ceramic surface cleans itself with every use. The VB2 is also optimized with an auto-off control so that you don’t have to worry about it remaining hot if you forget to turn it off before you leave the house or go to sleep.

The VB2 has a multi-use design, making it ideal for both medicinal and recreational consumers. If you don’t want to use the hose (also known as a whip), you may connect your VB2 directly to your percolator for an all-glass air-path like the image below.

vapor brothers vb2 review

Warranty

While a super warranty is built into the cost of the VB2, consumers may also choose to add a lifetime replacement warranty. The built-in warranty already includes free fixes of any defects, and if you have to send your VB2 back for any reason, they will update the vaporizer at no extra cost.

What impressed me most about Vapor Brothers, other than the exceptional quality of it’s products, is how dedicated they are to customer satisfaction. This is a company that cares more than it sells, so I can absolutely recommend the VB2 and any other Vapor Brothers products with complete confidence.

Another positive aspect about ordering Vapor Brothers products is that they are willing and able to accommodate special requests for an extra cost, so don’t be afraid to ask for a customization like the one below.

Click here to buy the VB2 now. You have to try it for yourself to believe it.

vb2 vaporizer review

Denver Cannabis Tourism

Denver Cannabis Tourism

Colorado has been a tourist destination since before it became a state in 1876. The beauty of the rough landscape and the Rocky Mountains is undeniable, even to those who aren’t normally inspired by such natural majesty. Traditionally, the tourism enjoyed by the Centennial State has been for activities such as skiing, fishing, hunting, camping, hiking, and nature photography. In 2016, however, cannabis tourism, or cannatourism, must officially be added to the list. Needless to say, those interested in such excursions should be 21 or older.

It has been two full years since Colorado became the first state in the nation to legalize adult use cannabis. Since its debut, sales of permitted pot has poured tens of millions of dollars in tax revenues into the coffers of the state’s municipalities and school districts. A significant part of this growth — and much of the money — has been generated via cannabis tourism.

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Some ski town dispensaries have claimed that 60-80 percent of their business is derived from those traveling from out-of-state, typically on a personal vacation. Frustrated fans of cannabis in prohibitionist states are visiting Colorado in record numbers, seeking a taste of freedom and regulated safe access, similar to how North Americans used to travel to Amsterdam to sample a more liberated environment for cannabis consumption and fellowship. 

Toking in Legal Limos

Cannatourism services are available in many forms. These include cannabis-friendly limos that will make a beeline from Denver International Airport to the nearest reputable dispensary, specialty tours that explore quaint mountain dispensaries, and cannabis-friendly hotels and bed and breakfasts. The future may even bring cannacafes and social gathering places for cannabis consumers, much like how those who enjoy alcohol can visit a tavern or pub.

Let’s spend a fantasy weekend in Denver, a city that — much like Portland and Seattle — is becoming a mecca for patients and lifestyle cannabis consumers who prefer to partake of strains like the rare sativa Durban Poison or top shelf samples of Girl Scout Cookies when vacationing. Given the stress of modern life, a weekend learning about and responsibly consuming cannabis, in a variety of forms and among plenty of fellow enthusiasts, might be just the ticket to managing anxiety and maintaining a healthy, balanced perspective on life, including family and career.

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The first stop on this cannabis vacation isn’t a stop at all, but rather a ride in the 420 Airport Pickup limo that travels directly to the dispensary that best caters to one’s preferences. Really into concentrates? How about edibles? Want to try that hip new whole plant extract called live resin? Given the number of specialty shops in the Denver metro area, this canna-shuttle can help, allowing patients to medicate before they even reach their lodging. This company also offers cannabis tours and a nice discount to those who purchase a round trip. Travel back to the airport in style — and avoid the worry and hassle of returning a rental car or getting busted while driving stoned.

Canna-friendly Lodging

Stocked up on cannabinoid-rich medicine, the next stop is the hotel. There are many options for canna-friendly lodging in the Mile High City, including a chain of locations by Bud+Breakfast and a premier downtown hotel that just happens to allow residents to toke up in its sumptuous suites. Bud+Breakfast (the company with the tag line “We’ll keep the bowl burning for you”) offers multiple properties, including the famous and classically beautiful Adagio Bed & Breakfast in Capital Hill, as well as multiple mountain cabin properties.

Located in one of Denver’s most beautiful historic neighborhoods, the Adagio B&B is a beautiful Victorian — and a stark contrast from the company’s cabin properties that are nestled within the mountains. The Adagio offers six “elegantly decorated” private suites that range from $200 to $300 per night and provide ready access to the attractions of downtown — including dispensaries and retail outlets.

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At $300 a night, the company’s smoke-friendly cabin in Aspen isn’t cheap, but considering that it provides the utmost in beautiful mountain scenery and consummate privacy for up to six adults, it can actually be very reasonable. Another option is this hospitality company’s cabin in Silverthorne, Colorado, which offers five suites priced from $130 to $250 per night and is perfect for a romantic getaway while vaping a nice concentrate or smoking some sticky buds purchased at the dispensary stop on the drive from the airport.

Another option is The Nativ, a swank hotel in downtown Denver that just so happens to be friendly to cannabis (and owned by culture-friendly entrepreneurs and advocates). This luxury destination offers 24-hour room service and features suites replete with a 60-inch high-definition display panels, private patios, and oversized hot tubs. The Nativ’s focus on luxury may not appeal to the more bohemian members of the cannabis culture or those on a budget, with room rates ranging from $330 to $535 per night.

However, those who prefer or are habituated to high-end accommodations, especially international business travelers, will appreciate the ability to smoke or vape without risk of being booted from their room or paying a ridiculously steep fine for having smoked in it. Nativ offers a rare mix of old school luxury and a 21st century respect for cannabis consumers, including a coffee and champagne bar and the ability to chill in style with several friends in a full-size Jacuzzi — or by oneself with a bowl of medical-grade flowers or a handy vape pen. All legally purchased and consumed.

Tours

Denver is nothing is not a hotspot for cannabis themed tours of nearly every shape and size. Many focus on dispensaries, while some offer tours of large cultivation facilities. Others focus on mountain vistas and dispensaries or retail shops that serve the slice of the skiing community that embraces cannabis for mind, body, and spirit.

The High There Bus, dubbed the Hopper, is a 20-passenger limo-style, cannabis-friendly party bus that tours Denver. But there’s a catch: Tour guests are users of the High There app, a Tinder-style dating service targeted at cannabis users. The Hopper is a legal alternative for cannabis tourists who may find a lack of desire to violate their hotel smoking policy or toke in public and risk encountering a strict police officer.

What is interesting about the Hopper, which debuted in 2016, is that it is free to ride. It is legal and, theoretically, safe to consume cannabis on this party bus, but the intent is obviously to promote the High There app. Until cannabis lounges and bars emerge that allow safe, casual use of cannabis for tourists, the Hopper will be a valid alternative — for those who are willing to sign up for the High There dating service, that is.

Some of the best, and most affordable, tours in Denver are offered by My 420 Tours, which features dispensary and grow tours beginning at only $50. A unique Sushi and Joint Roll dinner is available for $60 per person. Most tours, including the four-hour Budz & Sudz Tour (that includes time in a brewery tour, a tasting session, and dinner), carry a $100 fee, including a popular cannabis cooking class.

There’s no doubt that Denver currently offers some of the best, and most interesting, cannabis-centric tours in the nation. Another example is Cultivating Spirits, a tourism company offering a range of unusual cannabis excursions, including a three-course “cannabis pairing” dinner and a Food, Wine, and Cannabis tour.

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For foodies who love to consume superlative cannabis, get the munchies, and dine in style, Cultivating Spirits is a dream come true. Wine fans who would never walk into an incense-drenched head shop may love the classy tours offered by this company. Although pricey (the Food, Wine, and Cannabis tour is $250 per person, but offers the advantage of being limited to only 10 guests), tours from this company last several hours and have received praise from picky guests. Said one customer:

“I was taken care of the whole night by the guide, never having an empty glass, dull moment, or question unanswered.”

Another credible source of pot-friendly tours is Colorado Highlife Tours, which proudly proclaims that it has been providing “safe, fun, and discreet” tours since 2013. The Denver Stony Saturday Tour, which costs $90, is a 3-4 hour sight seeing jaunt that allows guests to smoke or vape while riding the party bus. The tour includes stops at a glass blowing shop and an indoor cultivation facility, as well as a 4:20 pm smokeout that makes available vaporizers, dab rigs, and water pipes. Guests can smoke or vape virtually any way they desire — even if they come to the party unprepared in terms of a smoking implement.

The Unique Stuff

From the perspective of its psychoactive effect and euphoria, cannabis is known to both generate and enhance creativity. For painters, those who practice yoga and meditation, and many other artists or creative types, pot is arguably a performance enhancer, aiding sometimes intrepid artistic efforts for both amateurs and professionals alike. For many, cannabis eliminates “writer’s block.”

Puff, Pass, and Paint is one of the more successful, as well as unique, cannabis-centric businesses that has emerged during the dawn of the age of adult use legalization that began in Colorado in 2014. Offering classes in the three top legal cannabis hotspots — Seattle, Portland, and Denver — this funky “cannabis-friendly, all-inclusive art class” is both daring and rewarding in its embrace of students puffing down or vaping their own herb or oil while trying to get inspired to create, learn, paint, and mingle.

A new class in the mix is Puff, Pass, and Pottery. Class fees are very reasonable and range from about $50 to $65. Said the chain’s owner, Heidi Keyes, “Puff, Pass, and Paint is a 420-friendly art class, which basically means that it is providing an environment to come and create — and feel very comfortable doing that.” She added:

“And also to be able to partake in cannabis, if you choose to.”

Those wishing to break from the traditional couples vacation should seriously consider Denver and the entire state of Colorado for their next adventure. A full catalog of services allows patients and consumers of all age groups and budgets.

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The only unfortunate thing is the fact that cities like Denver, Seattle, and Portland are among the very few places in all of the United States where patients and fans of the cannabis culture can travel to enjoy legal adult access to regulated, lab tested, high-quality cannabis medicine and related products and services. Hopefully this will change in the coming years, especially if more states legalize adult use in the 2016 elections.

Some Advice for Cannatourists

One final piece of advice, especially for novice cannatourists. Those interested in Colorado edibles should seriously heed the mantra start low, go slow. Good tours will expose guests to professional budtenders who will preach likewise and give real world dosing (titration) advice to customers, with a full slew of warnings for first-time consumers. Due to the abundant sources of safe, tested, and properly labeled edibles in the state, visitors are warned to avoid edibles from the black market.

Photo credit: Bud+Breakfast (The Maryjane Group), Puff Pass and Paint, My 420 Tours

Landrace Strains: The Beginning of Cannabis

Landrace Strains: The Beginning of Cannabis

Participants in the cannabis culture may be familiar with a few of the rare varieties of the plant that are categorized as landrace strains, including Colombian Gold, Durban Poison, Northern Lights, and Afghan Kush. “Landrace” simply refers to the small number of surviving strains of cannabis that evolved naturally in the geographic region in which they were initially discovered (by 20th century humans, that is). Some experts believe that about 100 of these rare strains exist today.

Landrace strains hail from global regions such as Jamaica, Afghanistan, India, Africa, Mexico, Pakistan, and Central America. They are believed to have originated in the Hindu Kush region of Pakistan and Afghanistan. This is one reason that so many strain names incorporate the term “Kush,” such as the always-popular OG Kush (the “OG” means “Ocean Grown,” denoting West Coast breeding and cultivation).

Many cultivators believe that the best examples of cannabis sativa are grown in a region as close to the equator as possible and at a relatively high elevation. Thus, mountainous areas in Central America, the Middle East, Africa, and Indonesia are almost perfectly suited to the cultivation of high-quality cannabis. This is no coincidence; landrace strains hail from most of these regions. Technically, landrace strains are those that have stabilized over time as a result of natural inbreeding.

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Other definitions of landrace cannabis include any that hasn’t purposefully been bred or otherwise manipulated by humans. Such indigenous varieties of marijuana, because they have evolved within a particular region, are very precisely acclimated to their local climates — and may offer unique medicinal qualities that are specifically tuned to the native humans of that region. Wrote Rick Pfrommer, Director of Education at Harborside Health Center, one of the nation’s largest dispensaries:

“It’s not that [landrace strains are] necessarily better, [they’re] just different, and perhaps more effective for some patients’ specific conditions or needs.”

Source of All Modern Strains

Many readers aren’t interested in a history lesson, however. How are landrace strains related to modern varieties and hybrids? Put simply, landraces are the origin of all modern cannabis strains. They are the genesis of cannabis in society and reflect its state of development, or evolution, before modern humans began breeding and cultivating the herb for medicine, lifestyle enhancement, and profit.

Cannabis breeders long ago took original landrace strains and bred, or crossed, them in an effort to create new strains possessing the best characteristics of both parents (and, just as with dogs or humans, hopefully few of their bad traits). Some strains feature shorter growing periods or are more resistant to pests or mold, making them the desire of cultivators. Others, especially sativa varieties, may be more difficult to grow and feature relatively long flowering cycles, but can also deliver unique medicinal and psychoactive effects that are sought by many patients and cannabis consumers.

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For all practical purposes, it must be assumed that many landrace strains, in their original, pure form, have been lost forever. Endless crosses over several decades in most areas of the world, especially North America, the United Kingdom, and Europe, have resulted in diluted genetics. The sad reality is that many “pure” breeds of cannabis are often mislabeled. Many purported examples of seeds, harvested cannabis flowers, or concentrates from pure landrace strains are inevitably not. Instead, they are sometimes the descendents of multiple landraces that have been bred (either purposefully or accidentally), going back an unknown number of generations — and with possibly very different characteristics. Also, genetic mutations easily emerge, especially under different growing conditions, which can cause great stress to mature plants.

For decades, strains have been bred to bring out their potency, especially in terms of tetrahydrocannabinol, or THC, the cannabinoid in the plant that delivers psychoactive effects and is largely responsible for its euphoria — but also is a powerful medicine for dozens of diseases. However, researchers and medical professionals have identified something called the entourage effect that supports the concept of whole flower medicine by observing that cannabinoids and terpenes interact synergistically, in a delicate and nuanced supplementation of the human body’s endocannabinoid system.

The good news is that a significant portion of the cannabis breeding community has been focused on creating strains that deliver the greatest medicinal value. Many modern varieties of cannabis are a far cry from the original strains from which they are descended. Just as a modern human living in Kentucky might be a descendant of American founding father Benjamin Franklin while, in most respects, the two humans are very different, cannabis strain crosses often, in reality, feature a morphology (shape and size), growing characteristics, and high type that is very different from their landrace ancestors. Sometimes, crosses and hybrids are more appropriate and therapeutic than landrace strains for particular diseases or ailments.

Understanding Phenotypes and Heirlooms

When seeds from landrace strains are cultivated outside the zone in which they evolved, they produce what geneticists and breeders label phenotypes. Phenotypes are transmogrifications of the plant that result in similar, but different characteristics. This includes morphology, development (such as the length of flowering cycles), and biochemical properties (potency and cannabinoid/terpene profiles). Phenotypes that are direct descendents of landrace strains, with no breeding or crossbreeding, are known as heirlooms.

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In landrace strains grown outside their area of origin, a change occurs in the cannabinoid and terpene profiles of the resinous trichomes found on the female flowers of these heirloom varieties. Because they necessarily receive different light cycles, sometimes artificial light instead of natural, and different soil (not to mention dramatic variances in water, humidity, and nutrition), these strains must modify and adapt to their new environments. This changes the inherent characteristics of these strains, including their medical efficacy and high type.

Because they have evolved over hundreds of thousands or even millions of years, landrace strains are considered to be more “balanced,” with terpene and cannabinoid profiles that are in harmony with the needs of the plant, its environment, and — in theory — the humans and animals living in the region that consumed it. (All mammals have an endocannabinoid system and, therefore, are affected by cannabis in a manner similar to humans.)

Origin of American Cultivation Culture

The cannabis cultivation cultures in Northern California and Hawaii have their genesis in heirloom strains introduced to the United States during the 1960s, ’70s, and ’80s. The climate in Northern California sometimes closely approximates that of parts of Afghanistan and the Hindu Kush mountains. Because the central West Coast of the United States is roughly similar in the weather it receives, landrace strains brought back from some regions of Indonesia and the Middle East have traditionally thrived in Northern California. With them, the cannabis culture in the United States has also thrived. Both Hawaii and the entire West Coast have become synonymous with high-quality outdoor grown cannabis — just as Columbia is known for producing some of the world’s best coffee beans.

Patients and lifestyle consumers wishing to expand their cannabis horizons should seek out landrace and heirloom strains in an effort to learn more about the roots of cannabis in not only North America, but throughout the world. Cultivators wanting a change of pace should strive to obtain seeds and clones (cuttings) from heirloom strains in an effort to keep them alive for current and future generations and give patients (and medical professionals, including researchers) additional options for cannabis medicine.

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Classic Landrace Strains

In the past, landrace strains that happened to be sativas were eschewed by gardeners for indicas and crosses that featured shorter flowering periods. This was simply because these varieties were more profitable for commercial cultivators. However, the recent wave of recreational and medical cannabis laws at the state level in the U.S. has spawned markets for special strains, many of which are landrace sativas (such as Durban Poison).

Examples of popular and classic landrace strains include the following:

  • Afghan Kush: A pure indica strain purported to have originated in the Hindu Kush Mountains between Pakistan and Afghanistan.
  • G13: A landrace from Afghanistan that typically leans toward indica. However, two phenotypes of this strain exist, the second of which is a sativa.
  • Durban Poison: An unusually potent sativa from the South African port city of Durban. Click here to read an expert review of this strain.
  • Acapulco Gold: The infamous landrace sativa that hails from the Acapulco region of Southwest Mexico and typically features high levels of THC.
  • Northern Lights: A legendary indica, this highly inbred Afghani is purported to hail from British Columbia.
  • Rooibaard: A sativa from the coastal area of the Transkei region of South Africa.
  • Colombian Gold: The fabled cannabis hybrid that is sometimes a bit sativa-dom that originates in the Santa Marta mountains of Colombia in Central America.
  • Hawaiian: A sativa-dom hybrid from the islands of Hawaii.
  • Malawi Gold: A pure sativa is from the Salima region of Malawi in Southeast Africa.
  • Thai: A sativa from, as its name implies, Thailand. Hybrids derived from Thai include Fruity Thai and Juicy Fruit Thai.
  • Panama Red: This sativa from Panama became popular in the late 1960s, during the hippy psychedelic era.
  • Punto Rojo: A sativa from Columbia that is considered by some to be even better than Colombian Gold.
Linalool Cannabis Terpene

Linalool Cannabis Terpene

Many are familiar with the major cannabinoids found in cannabis, such as THC and CBD, which have such great efficacy for conditions like depression, PTSD, and epilepsy. But cannabinoids are only part of the picture. Terpenes are like molecular cousins to cannabinoids and serve the primary role of delivering a wide variety of alluring aromas to cannabis flowers, but also offer a wide range of medicinal benefits as well.

In addition to aroma, terpenes deliver sometimes great medicinal value. They have been found to fight cancer and act as an analgesic (pain killer). Like amino acids, terpenes are powerful building blocks within the plant’s physiology that aid in the production of vitamins, hormones, pigments, resins, and — yes, that most prized part of the herb — cannabinoids. Cannabis plants release more terpenes when temperatures are higher (one reason they emit strong odors during the peak of harvest season).

Understanding Terpenes

More than 200 terpenes are available in the cannabis plant, while more than 20,000 exist in nature. They are produced in the small resin glands that appear primarily on the surface of the flowers and sugar leaves of cannabis plants called trichomes. It is estimated that there are nearly 1000 strains of cannabis that have been bred. Each of these features a distinct and unique mix of terpenes, something called a terpene profile.

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Cannabis and cannabis products — such as concentrates — sold in legal and regulated states often feature a label providing a laboratory analysis that lists the exact percentages of cannabinoids and terpenes. Often, lab techs, budtenders, and pot nerds will discuss particular strains or extracts of cannabis in terms of their terpene profiles and how the overall efficacy of one profile (an individual of a particular strain) compares with other samples or methods of extracting concentrates.

Major terpenes include myrcene, pinene, and limonene. Myrcene, which conveys earthy and clove-like odors, determines whether a particular strain is indica or sativa by its percentage within the plant (further illustrating the important role played by terpenes). Pinene, a terpene also found in evergreens, has been found to increase mental focus and energy and acts as a bronchodilator — making it helpful for asthma sufferers. Limonene, as its name implies, provides an aroma of citrus and is found not only in cannabis, but also oranges, grapefruits, lemons, and limes. It has been revealed to alleviate depression and aid in digestion.

Terpenes are very volatile, delicate molecules that are easily destroyed by heat and oxidation. Popular cannabis concentrates, like BHO and CO2 oil, are mostly void of terpenes. One new extraction method called live resin preserves the terpene profile of cannabis plants. This process involves cryogenically freezing plants immediately after harvest and then using a laboratory extraction process (backyard brewers need not apply) to remove and isolate a more accurate representation of a particular plant’s mix of cannabinoids and terpenes.

What is Linalool?

Linalool, one of the minor terpenes found in cannabis, conveys a floral aroma, sometimes with a hint of spice. More than 200 species of plants produce linalool, including a variety of mints and herbs. More important, linalool serves many roles in relieving a number of symptoms, including pain, depression, seizures, inflammation (similar to limonene), and even insomnia (because it acts as a sedative). Its tranquilizing effects are helpful for those suffering with many types of psychosis.

  • Analgesic: Linalool is helpful for conditions like multiple sclerosis, dystonia, arthritis, post-operative pain, and chronic pain from any source because it is a pain killer. Combined with cannabinoids of the same efficacy, linalool can be a reinforcing agent in a patient’s struggle to manage pain, especially if they are trying to avoid or reduce use of opiates such as Vicodin, Percocet, and Oxycontin.
  • Antidepressant: More than 20 million people in the United States alone suffer from sometimes debilitating depression. This common psychological ailment can negatively affect one’s career, personal relationships, and even physical health. Linalool, when combined with cannabinoids like THC that are also effective in helping alleviate depression, helps form an overall strategy for using cannabis to treat these types of disorders.
  • Anti-Convulsant: Just as chemotherapy is used to treat conditions other than cancer, seizures afflict those with conditions other than epilepsy, such as traumatic brain injury, brain tumors, and hydrocephalus. Most seizures feature a duration of between 30 seconds and two minutes. Typically, they do not cause lasting harm, although they seizures often very taxing, painful, or exhausting for sufferers. Seizures that last longer than five minutes are considered life threatening.
  • Anti-Inflammatory: Those suffering from inflammation-based diseases, such as Crohn’s, arthritis, Alzheimer’s, asthma, fibromyalgia, dermatitis, IBS, lupus, and Parkinson’s, among many others, gain benefit from the anti-inflammatory properties of linalool (as well as a variety of anti-inflammatory cannabinoids).
  • Sedative and Sleep Aid: It is estimated that 10-30 percent of people suffer from insomnia at some point in their lives, with 10 percent reported to experience chronic and severe sleep deprivation. Cannabinoids like CBN, when combined with terpenes such as linalool, help patients get the sleep they require to maintain homeostasis (balance) and health. Adequate sleep is critical for patients to most effectively fight their condition or disease.

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The  Studies

Ancient cultures have used terpenes like linalool, available in a variety of aromatic herbs like cannabis, for millennia to treat a wide variety of conditions. 21st century research has confirmed the beliefs of these ancient civilizations, revealing strong medical efficacy for a variety of conditions.

A 2002 study published in the Journal of Phytomedicine revealed that linalool is a major anti-inflammatory agent, potentially helping with a variety of inflammation-related ailments, such as cancer, arthritis, and Crohn’s disease. The same research team, in a 2003 study, found linalool to also be a pain killer. These researchers again, in 2006, conducted another linalool study that further collected and examined data from animal models. This study reinforced the fact that linalool is a powerful anti-inflammatory.

2008 research published in the American Association of Nurse Anesthetists Journal supported the sedative qualities of linalool. The study estimated that 19 million Americans suffer from anxiety-related ailments, with 16 percent of people between the ages of 18 and 54 being patients of one or more anxiety conditions, which sometimes lead to substance abuse and mood disorders.

This study revealed linalool to be a powerful sedative that delivers real efficacy to those who suffer anxiety disorders and one of their most common side effects, insomnia. Concluded the study:

“Our data…suggested that linalool modulates the central nervous system by producing unconsciousness and degradation of motor movements.”

linalool cannabis

A 2010 study involving mice that employed three different sub-types of linalool found it to be an effective anticonvulsant, meaning it shows significant promise for those who suffer seizures, such as patients of epilepsy and brain tumors. Reported the study:

“Linalool…[was] effective in preventing tonic convulsions induced by transcorneal electroshock in the animals.”

More Research Needed

As with all areas of cannabis science, terpenes like linalool are in desperate need of well funded, robust research in the form of human trials. Until cannabis is dropped from Schedule I and real studies are permitted by reputable research institutions and laboratories, medical professionals and patients must play a guessing game in terms of the types and dosages of terpenes like linalool that are most appropriate for particular conditions.

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